Brzezinski A, Peretz T, Mor-Yosef S, Schenker J G
Department of Obstetrics and Gynecology, Hadassah Medical Center, Hebrew University Hadassah Medical School, Jerusalem, Israel.
Gynecol Oncol. 1994 Mar;52(3):292-5. doi: 10.1006/gyno.1994.1051.
The results of both epidemiologic and experimental studies suggest that endogenous (and apparently exogenous) sex hormones and other reproductive variables have an important role in the development of human breast neoplasia. Nevertheless, no controlled study has ever addressed the possible effects of ovarian stimulation on the incidence and course of human breast cancer. Over the past decade the number of women undergoing follicular stimulation, especially during assisted reproductive technology procedures, has grown rapidly. Here we present 16 cases of young women who were treated by induction of ovulation, and subsequently were diagnosed with breast cancer. These women were drawn out of 950 cases of infertile women who underwent induction of ovulation at our fertility clinic over a 10-year period. The possible association between ovarian stimulation and promotion of breast cancer is discussed and the need for a controlled study is emphasized.
流行病学和实验研究的结果均表明，内源性（显然还有外源性）性激素及其他生殖变量在人类乳腺肿瘤的发生发展中起着重要作用。然而，尚无对照研究探讨过卵巢刺激对人类乳腺癌发病率和病程的可能影响。在过去十年中，接受卵泡刺激的女性数量迅速增加，尤其是在辅助生殖技术过程中。在此，我们报告16例接受排卵诱导治疗后被诊断为乳腺癌的年轻女性病例。这些女性来自我们生育诊所10年间接受排卵诱导治疗的950例不孕女性。本文讨论了卵巢刺激与乳腺癌发生之间的可能关联，并强调了进行对照研究的必要性。
