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韩国红参中的二醇型人参皂苷可延缓糖尿病倾向生物繁殖大鼠1型糖尿病的发展。

Diol-ginsenosides from Korean Red Ginseng delay the development of type 1 diabetes in diabetes-prone biobreeding rats.

作者信息

Ju Chung, Jeon Sang-Min, Jun Hee-Sook, Moon Chang-Kiu

机构信息

College of Pharmacy, Seoul National University, Seoul, Republic of Korea.

College of Pharmacy and Research Institute of Pharmaceutical Science and Technology (RIPST), Ajou University, Suwon, Gyeonggi-do Republic of Korea.

出版信息

J Ginseng Res. 2020 Jul;44(4):619-626. doi: 10.1016/j.jgr.2019.06.001. Epub 2019 Jun 12.

DOI:10.1016/j.jgr.2019.06.001
PMID:32617042
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7322746/
Abstract

BACKGROUND

The effects of diol-ginsenoside fraction (Diol-GF) and triol-ginsenoside fraction (Triol-GF) from Korean Red Ginseng on the development of type 1 diabetes (T1D) were examined in diabetes-prone biobreeding (DP-BB) rats that spontaneously develop T1D through an autoimmune process.

METHODS

DP-BB female rats were treated with Diol-GF or Triol-GF daily from the age of 3-4 weeks up to 11-12 weeks (1 mg/g body weight).

RESULTS

Diol-GF delayed the onset, and reduced the incidence, of T1D. Islets of Diol-GF-treated DP-BB rats showed significantly lower insulitis and preserved higher plasma and pancreatic insulin levels. Diol-GF failed to change the proportion of lymphocyte subsets such as T cells, natural killer cells, and macrophages in the spleen and blood. Diol-GF had no effect on the ability of DP-BB rat splenocytes to induce diabetes in recipients. Diol-GF and diol-ginsenoside Rb1 significantly decreased tumor necrosis factor α production, whereas diol-ginsenosides Rb1 and Rd decreased interleukin 1β production in RAW264.7 cells. Furthermore, mixed cytokine- and chemical-induced β-cell cytotoxicity was greatly inhibited by Diol-GF and diol-ginsenosides Rc and Rd in RIN5mF cells. However, nitric oxide production in RAW264.7 cells was unaffected by diol-ginsenosides.

CONCLUSION

Diol-GF, but not Triol-GF, significantly delayed the development of insulitis and T1D in DP-BB rats. The antidiabetogenic action of Diol-GF may result from the decrease in cytokine production and increase in β-cell resistance to cytokine/free radical-induced cytotoxicity.

摘要

背景

在通过自身免疫过程自发发展为1型糖尿病（T1D）的糖尿病易感性生物繁殖（DP-BB）大鼠中，研究了韩国红参二醇型人参皂苷组分（Diol-GF）和三醇型人参皂苷组分（Triol-GF）对T1D发生发展的影响。

方法

从3 - 4周龄至11 - 12周龄，每天给DP-BB雌性大鼠给予Diol-GF或Triol-GF（1 mg/g体重）。

结果

Diol-GF延缓了T1D的发病并降低了其发病率。经Diol-GF处理的DP-BB大鼠胰岛显示出明显较低的胰岛炎，且血浆和胰腺胰岛素水平保持较高。Diol-GF未能改变脾脏和血液中淋巴细胞亚群（如T细胞、自然杀伤细胞和巨噬细胞）的比例。Diol-GF对DP-BB大鼠脾细胞诱导受体发生糖尿病的能力没有影响。Diol-GF和二醇型人参皂苷Rb1显著降低肿瘤坏死因子α的产生，而二醇型人参皂苷Rb1和Rd降低RAW264.7细胞中白细胞介素1β的产生。此外，Diol-GF以及二醇型人参皂苷Rc和Rd在RIN5mF细胞中极大地抑制了混合细胞因子和化学物质诱导的β细胞细胞毒性。然而，二醇型人参皂苷对RAW264.7细胞中一氧化氮的产生没有影响。

结论

Diol-GF而非Triol-GF显著延缓了DP-BB大鼠胰岛炎和T1D的发展。Diol-GF的抗糖尿病作用可能源于细胞因子产生的减少以及β细胞对细胞因子/自由基诱导的细胞毒性的抗性增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab77/7322746/4591a941812f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab77/7322746/b3ce4cb37117/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab77/7322746/246d5d62eb38/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab77/7322746/eb7425d1fa11/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab77/7322746/b954c2e20633/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab77/7322746/4753388222c7/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab77/7322746/4591a941812f/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab77/7322746/b3ce4cb37117/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab77/7322746/246d5d62eb38/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab77/7322746/eb7425d1fa11/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab77/7322746/b954c2e20633/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab77/7322746/4753388222c7/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ab77/7322746/4591a941812f/gr6.jpg

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