Buckshee K, Roy K K, Verma I C
Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi.
Indian J Pediatr. 1993 Sep-Oct;60(5):655-7. doi: 10.1007/BF02821728.
A prospective study was undertaken in North India to find the normative data on the nuchal fold thickness of randomly selected 150 fetuses between 16-22nd week of gestation. The data revealed that the width of nuchal fold thickness ranged between 2-5 mm. The mean for 16-18, > 18-20, and > 20-22 week's gestation was 2.6 +/- 0.2, 3.8 +/- 0.9, and 4.0 +/- 0.8 mm respectively. In one fetus nuchal fold thickness was 6mm at 18 weeks (> 2SD above the normal value) and thus Down Syndrome was suspected. This was later confirmed by amniocentesis and karyotyping.
在印度北部开展了一项前瞻性研究，以获取150例随机选取的妊娠16至22周胎儿颈部褶皱厚度的标准数据。数据显示，颈部褶皱厚度的范围在2至5毫米之间。妊娠16至18周、大于18至20周以及大于20至22周的平均厚度分别为2.6 +/- 0.2毫米、3.8 +/- 0.9毫米和4.0 +/- 0.8毫米。在一名妊娠18周的胎儿中，颈部褶皱厚度为6毫米（高于正常值2个标准差以上），因此怀疑患有唐氏综合征。这一诊断后来通过羊水穿刺术和染色体核型分析得到了证实。
