Benacerraf B R, Frigoletto F D
Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Am J Obstet Gynecol. 1987 Nov;157(5):1146-9. doi: 10.1016/s0002-9378(87)80279-x.
There are several reports describing the sonographic sign of a thickened nuchal fold for the prenatal sonographic detection of Down syndrome in the second trimester. We prospectively obtained normative data on the nuchal folds of 303 consecutive normal fetuses undergoing genetic amniocentesis between 15 and 20 weeks' gestation. The data show that the width of the nuchal fold was consistently between 1 and 5 mm regardless of gestational age (15 to 20 weeks).
有几份报告描述了孕中期超声检查时增厚的颈部褶皱这一超声征象，用于产前检测唐氏综合征。我们前瞻性地获取了303例连续正常胎儿颈部褶皱的规范数据，这些胎儿在妊娠15至20周期间接受了遗传羊膜穿刺术。数据显示，无论孕周（15至20周）如何，颈部褶皱的宽度始终在1至5毫米之间。
