Lenoir S, Rhabbour M, Grandjean B, Fournié A, Rolland M
Unité INSERM CJF 8908, Hôpital La Grave, Toulouse.
J Gynecol Obstet Biol Reprod (Paris). 1994;23(1):93-5.
Angiotensin converting enzyme inhibitors do not have any teratogenic effect in man but their use during pregnancy has led to cases of hypotension and subsequent severe renal failure in the newborn. The authors report two cases, one involving a twin pregnancy which illustrate the variability of the foetal involvement. It is emphasized that the side effects of angiotensin converting enzyme inhibitors are not only reversible but also are not constantly found.
血管紧张素转换酶抑制剂对人类没有任何致畸作用，但在怀孕期间使用这些药物已导致新生儿出现低血压及随后的严重肾衰竭病例。作者报告了两例病例，其中一例为双胎妊娠，这两例病例说明了胎儿受累情况的可变性。需要强调的是，血管紧张素转换酶抑制剂的副作用不仅是可逆的，而且并非始终都会出现。
