Redondo Granado M J, Alvarez Guisasola F J, Blanco Quirós A
Departamento de Pediatría, Hospital Universitario, Valladolid.
Med Clin (Barc). 1994 Feb 19;102(6):201-4.
Analysis of blood lead levels in relation to the state of iron metabolism was carried out in children.
A transversal study of blood lead levels was designed in 89 iron deficient children (serum ferritin < 15 micrograms/l) (group F). Fifty seven of the children did not have anemia (sub-group FS) and 32 had anemia (sub-group AF) with ages ranging between 6 months and 14 years, and 41 children of the same age with normal iron metabolism (group C). A longitudinal study was also carried out by the determination of blood lead levels prior and after iron therapy in 18 of the iron deficient children.
A significant difference was seen between the mean of blood lead levels in iron deficient children (group F), 9.41 micrograms/dl and normal children (group C), 6.88 micrograms/dl (p < 0.01). The mean of blood lead levels of the sub-group FS was 7.79 micrograms/dl and the sub-group AF, 12.30 micrograms/dl (p < 0.01). The prevalence of lead poisoning (blood lead levels > 20 micrograms/dl) was 8% in group F (2% in sub-group FS, 19% in sub-group AF) and 0 in group C (p < 0.01). A significant decrease was found in the longitudinal study in the mean of blood lead levels following iron therapy from 14.12 micrograms/dl to 7.51 micrograms/dl (p < 0.05).
The iron deficient state may constitute a predisposing factor of lead poisoning in childhood.
对儿童血铅水平与铁代谢状态的关系进行了分析。
对89名缺铁儿童（血清铁蛋白<15微克/升）（F组）进行了血铅水平的横向研究。其中57名儿童无贫血（FS亚组），32名儿童有贫血（AF亚组），年龄在6个月至14岁之间，另有41名同龄铁代谢正常的儿童（C组）。还对18名缺铁儿童在铁治疗前后的血铅水平进行了纵向研究。
缺铁儿童（F组）的血铅水平均值为9.41微克/分升，正常儿童（C组）为6.88微克/分升，两者之间存在显著差异（p<0.01）。FS亚组的血铅水平均值为7.79微克/分升，AF亚组为12.30微克/分升（p<0.01）。F组铅中毒（血铅水平>20微克/分升）的患病率为8%（FS亚组为2%，AF亚组为19%），C组为0（p<0.01）。纵向研究发现，铁治疗后血铅水平均值从14.12微克/分升显著下降至7.51微克/分升（p<0.05）。
缺铁状态可能是儿童铅中毒的一个易感因素。
