Vermess M, Adamson R H, Doppman J L, Rabson A S, Herdt J R
Radiology. 1976 Apr;119(1):31-7. doi: 10.1148/119.1.31.
A new, lipoid-based experimental contrast material (AG 60-99) was intravenously infused into 29 rhesus monkeys. The injections resulted in dense hepatosplenograms, preserving diagnostic quality for over 24 hours, and enabling routine utilization of tomography. This technique is capable of demonstrating simulated hepatic masses as small as 5 mm in diameter in vivo. Limited histopathologic and toxicity studies showed no serious or lasting toxic manifestations from AG 60-99 and none of the animals died from it. AG 60-99 is felt to be potentially useful in the radiographic detection of early metastic or lymphomatous involvement of the liver and spleen.
一种新型的基于脂质的实验性造影剂（AG 60-99）被静脉注射到29只恒河猴体内。注射后产生了浓密的肝脾造影图，诊断质量保持超过24小时，并能使断层扫描得以常规应用。该技术能够在体内显示直径小至5毫米的模拟肝脏肿块。有限的组织病理学和毒性研究表明，AG 60-99没有严重或持久的毒性表现，也没有动物因它而死亡。AG 60-99被认为在肝脏和脾脏早期转移或淋巴瘤累及的影像学检测中可能有用。
