The growth hormone response to baclofen in obsessive compulsive disorder: does the GABA-B receptor mediate obsessive anxiety?
作者信息
Lucey J V, Butcher G, O'Flynn K, Clare A W, Dinan G
机构信息
Maudsley Hospital, London, United Kingdom.
出版信息
Pharmacopsychiatry. 1994 Jan;27(1):23-6. doi: 10.1055/s-2007-1014269.
PMID:8159779
Abstract
The growth hormone (GH) response to the gamma amino butyric acid type B (GABA-B) receptor agonist baclofen was measured in 10 Caucasian out-patients with DSM-III-R obsessive compulsive disorder (OCD) and 10 healthy comparison subjects. The patients also underwent a dexamethasone suppression test. The GH response was similar in both groups and there was a low rate of dexamethasone non-suppression in the patients. The data do not suggest that GABA-B receptor dysfunction is a feature of obsessive anxiety.
摘要
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