Heim W, Oelschläger H, Kreuter J, Müller-Oerlinghausen B
Biochemistry, Pharmacy and Food Chemistry Division, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.
Pharmacopsychiatry. 1994 Jan;27(1):27-31. doi: 10.1055/s-2007-1014270.
We investigated the rate of release of seven commercial lithium preparations designated as sustained-release preparations and available in Europe and the USA. The examined products release lithium completely within four hours. The rate of liberation from three drugs resembles that of nonsustained-release preparations, three of which were tested under the same conditions. In one case, the comparison between two batches of sustained-release preparations reveals marked differences in quality. Physicians should be aware that some drugs available on the market and designated as sustained-release preparations do not comply with the international standard for this type of formulation.
我们调查了欧洲和美国市场上七种宣称是缓释制剂的商用锂制剂的释放速率。检测的产品在四小时内可完全释放锂。三种药物的释放速率类似于非缓释制剂，其中三种在相同条件下进行了测试。在一个案例中，两批缓释制剂的比较显示出质量上的显著差异。医生应该意识到，市场上一些宣称是缓释制剂的药物并不符合这类制剂的国际标准。
