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[重组干扰素治疗迁延性病毒性肝炎患者的应用]

[The use of reaferon in treating patients with protracted viral hepatitis].

作者信息

Kokoreva L N, Zmyzgova A V, Nazarenko I V

出版信息

Ter Arkh. 1994;66(2):21-4.

PMID:8160137
Abstract

The paper reports the results of a randomized clinicoimmunological trial of domestic recombinant alpha 2-interferon (reaferon) in 30 patients with protracted viral hepatitis (27 subjects had viral hepatitis B and 3 patients HBV + HDV-coinfection). The reaferon treatment started on the disease week 7-8 and lasted for 2 months (1 x 10(6) IU, once a week, i.m.). VHB patients benefited from reaferon treatment as evident from improved clinical and laboratory indices, cases of complete cure and the agent elimination. In a protracted course of HBV + HDV coinfection reaferon in the above doses failed to produce any effect.

摘要

本文报告了国产重组α2干扰素(干扰能)治疗30例迁延性病毒性肝炎患者的随机临床免疫学试验结果(27例为乙型病毒性肝炎,3例为HBV+HDV重叠感染)。干扰能治疗于疾病第7 - 8周开始,持续2个月(1×10⁶IU,每周1次,肌内注射)。从临床和实验室指标改善、完全治愈病例及病毒清除情况来看,慢性乙型肝炎患者从干扰能治疗中获益。在HBV+HDV重叠感染的迁延病程中,上述剂量的干扰能未产生任何效果。

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