Solov'eva M A, Gorbacheva I N, Vikhoreva G A, Gal'braĭkh L S, Ryzhenkov V E
Vopr Med Khim. 1994 Mar-Apr;40(2):37-9.
Effect of commercially available preparations of chitosan sulfate on the total lipolytic activity was studied in rabbit blood. Chitosan sulfates, administered per os or intravenously, proved to be highly effective activators of lipolytic enzymes. The most distinct efficiency exhibited preparations with molecular mass of 60-120 x 10(3) and the rate of sulfation 1.20-1.35. After administration of the chitosan sulfates into hyperlipidemic rats a decrease in blood plasma VLDL and increased HDL content were observed.
研究了市售硫酸壳聚糖制剂对兔血中总脂解活性的影响。经口或静脉给药的硫酸壳聚糖被证明是脂解酶的高效激活剂。分子量为60 - 120×10³且硫酸化率为1.20 - 1.35的制剂表现出最显著的效果。给高脂血症大鼠施用硫酸壳聚糖后，观察到血浆极低密度脂蛋白（VLDL）减少，高密度脂蛋白（HDL）含量增加。
