Tomita T, Stranahan P
Virchows Arch B Cell Pathol. 1976 Mar 9;20(2):113-23. doi: 10.1007/BF02890332.
Glucose-induced insulin secretion was studied in isolated pancreatic islets from one to twelve week alloxan diabetic rats is 1/4 to 1/7 that of the controls. Insulin secretion by alloxan diabetic rat islets progressively diminishes with time after alloxan injection. The individual isolated islet gives insulin secretion of 54%, 27%, 15% and 19% of the controls at one, two, four and twelve weeks respectively. The estimeated total insulin secretion by all of the isolated islets from each pancreas is 11.0%, 5.4%, 3.1% and 2.8% of the controls by the one, two, four and twelve week alloxan diabetic rats. These results indicate beta cell loss is progressive with time until four weeks after alloxan injection when glucose-induced insulin secretion is characterized by a flat hyporesponsive curve indcative of completely deficient insulin secretion.
对1至12周龄四氧嘧啶糖尿病大鼠分离的胰岛中葡萄糖诱导的胰岛素分泌进行了研究，其分泌量为对照组的1/4至1/7。四氧嘧啶糖尿病大鼠胰岛的胰岛素分泌在注射四氧嘧啶后随时间逐渐减少。单个分离的胰岛在1周、2周、4周和12周时的胰岛素分泌量分别为对照组的54%、27%、15%和19%。来自每个胰腺的所有分离胰岛的估计总胰岛素分泌量，1周、2周、4周和12周龄四氧嘧啶糖尿病大鼠分别为对照组的11.0%、5.4%、3.1%和2.8%。这些结果表明，β细胞损失随时间逐渐加重，直到四氧嘧啶注射后四周，此时葡萄糖诱导的胰岛素分泌表现为平坦的低反应曲线，表明胰岛素分泌完全不足。
