Risk factors for cervical dysplasia in southwestern American Indian women: a pilot study.

Cervical cancer and cervical dysplasia occur at high rates among American Indian women in the southwestern United States. Few published data, however, have addressed risk factors for the development of cervical neoplasia among southwestern American Indian women. To investigate risk factors for cervical dysplasia in this population, we carried out a case-control pilot study focused on the effects of sexually transmitted diseases, sexual behavior, hygienic practices, cigarette use, contraceptive techniques, and diet in the development of cervical dysplasia. Although our pilot study lacked power to clearly identify risk factors for neoplasia, the data suggest that cervical papillomavirus infection (crude odds ratio 4.72, 95% confidence interval 1.62-14.11), vaginal deliveries (3.70, 0.69-20.04 for > 2 vaginal deliveries vs none), and current cigarette smoking (3.08, 0.50-24.15) were associated with dysplasia. These preliminary findings indicate that risk factors for dysplasia in American Indian women differ from risks which we have identified in southwestern Hispanic and non-Hispanic white women, and suggest the need for further investigation of ethnic differences in cervical disease development.