van der Putte S C
Department of Pathology, University Hospital, University of Utrecht, The Netherlands.
Am J Dermatopathol. 1994 Feb;16(1):23-30. doi: 10.1097/00000372-199402000-00005.
Apoeccrine glands were found in 13 of 57 specimens of nevus sebaceus. The glands showed the basic structure of eccrine glands, but differed in that a part of the secretory duct was lined by characteristic apocrine epithelium. The apocrine alteration varied from slight apocrine changes in a few secretory cells to an almost complete alteration of the secretory epithelium in other glands. The association with changes in the excretory ducts of rare glands suggested a transformation of eccrine into apocrine glands. It was nevertheless considered as most likely that a majority of the apocrine glands in nevus sebaceus had developed in the "classic" way in association with pilosebaceus structures. In nevus sebaceus, apoeccrine glands appeared to represent eccrine glands with a variable degree of apocrine metaplasia that could result in complete transformation rather than the formation of a separate category of specialized sweat glands. The capacity of eccrine epithelium to transform into apocrine epithelium is why difficulties are experienced in the precise categorization of sweat gland neoplasms into eccrine and apocrine tumors.
在57个皮脂腺痣标本中的13个发现了顶浆分泌性小汗腺。这些腺体显示出小汗腺的基本结构，但不同之处在于部分分泌导管内衬有特征性的顶浆分泌上皮。顶浆分泌性改变从少数分泌细胞的轻微顶浆分泌变化到其他腺体分泌上皮几乎完全改变不等。与罕见腺体排泄导管变化的关联提示小汗腺向顶浆分泌性汗腺的转化。然而，最有可能的是，皮脂腺痣中的大多数顶浆分泌性腺体是以与毛发皮脂腺结构相关的“经典”方式发育的。在皮脂腺痣中，顶浆分泌性小汗腺似乎代表具有不同程度顶浆分泌化生的小汗腺，这种化生可能导致完全转化，而不是形成一类单独的特殊汗腺。小汗腺上皮转化为顶浆分泌上皮的能力就是为什么在将汗腺肿瘤精确分类为小汗腺肿瘤和顶浆分泌性肿瘤时会遇到困难的原因。
