Sulica R L, Kao G F, Sulica V I, Penneys N S
Division of Dermatology, Georgetown University Medical School, Washington, D.C.
J Cutan Pathol. 1994 Feb;21(1):71-5. doi: 10.1111/j.1600-0560.1994.tb00694.x.
Eccrine angiomatous hamartoma (nevus) is a rare form of congenital tumorous malformation with proliferation of eccrine secretory coils and ducts, surrounding capillary angiomatous channels and occasionally other minor elements. To date, there have been only about 24 cases reported in the literature. We report an additional case with more detailed description of the microscopic findings, including immunohistochemical observations. The patient was a 28-year-old female who presented with painless, flesh- to reddish brown-colored, violaceous or bluish subcutaneous nodules on the extremities and trunk. The tumors did not show sweating following exertion. The histologic features were comparable to the previously reported cases. The hamartomatous eccrine sweat glands and ducts and a few apocrine glands demonstrated qualitatively diminished antigens commonly found in the eccrine sweat apparatuses, such as carcinoembryonic antigen (CEA) and S-100 protein. The findings of CD34, CD44, human nerve growth factor receptor and Ulex europaeus antigens have not been previously reported. The histologic features suggested a "hamartomatous" growth rather than a true neoplastic process.
小汗腺血管瘤性错构瘤（痣）是一种罕见的先天性肿瘤性畸形，其特点是小汗腺分泌盘曲小管和导管增生，周围有毛细血管血管瘤样通道，偶尔还有其他次要成分。迄今为止，文献中仅报道了约24例。我们报告了1例，并对显微镜下表现进行了更详细的描述，包括免疫组化观察结果。患者为一名28岁女性，四肢和躯干出现无痛性、肉色至红褐色、紫红色或蓝色皮下结节。肿瘤在运动后不出汗。组织学特征与先前报道的病例相似。错构瘤性小汗腺和导管以及少数大汗腺显示出小汗腺装置中常见抗原的定性减少，如癌胚抗原（CEA）和S-100蛋白。CD34、CD44、人神经生长因子受体和欧洲荆豆抗原的结果此前未见报道。组织学特征提示为“错构瘤性”生长而非真正的肿瘤形成过程。
