Sjögren U, Brandt L
Acta Haematol. 1976;55(2):73-80. doi: 10.1159/000207997.
Aspirates from bone marrow, spleen and liver were analyzed in 15 untreated patients with chronic myeloid leukaemia (CML). The proportion of erythroblasts was higher in the spleen and liver than in the bone marrow. An increased frequency of basophilic leucocytes was recorded in the extramedullary sites compared to the bone marrow. In the liver aspirates a considerable admixture of lymphocytes was found. The mitotic indices of the granulopoietic and erythropoietic precursor cells were lower in the spleen and liver than in the bone marrow. The results indicate that the composition and proliferative activity of the haemopoietic tissue differ in bone marrow and extramedullary sites in CML. The discrepancies may be due to differences in the microenvironment for the haemopoietic cells or to a selective accumulation of cells with a low mitotic activity in extramedullary sites. Since the final blastic transformation of CML may originate outside the bone marrow, further studies of the extramedullary haemopoietic tissue may be worthwhile.
对15例未经治疗的慢性髓性白血病（CML）患者的骨髓、脾脏和肝脏穿刺物进行了分析。脾脏和肝脏中幼红细胞的比例高于骨髓。与骨髓相比，髓外部位嗜碱性白细胞的频率增加。在肝脏穿刺物中发现有相当数量的淋巴细胞混合。脾脏和肝脏中粒细胞生成和红细胞生成前体细胞的有丝分裂指数低于骨髓。结果表明，CML患者骨髓和髓外部位造血组织的组成和增殖活性不同。差异可能是由于造血细胞微环境的差异，或由于髓外部位有丝分裂活性低的细胞选择性积聚。由于CML最终的原始细胞转化可能起源于骨髓外，因此对髓外造血组织进行进一步研究可能是有价值的。
