Sjögren U
Acta Haematol. 1978;59(4):231-6. doi: 10.1159/000207766.
Aspirates from bone marrow, spleen and liver were analysed in 10 untreated patients with idiopathic myelofibrosis (MF). The proportion of erythroblasts was higher in the spleen and the liver than in the bone marrow. The mitotic indices of the erythropoietic precursor cells were subnormal in the extramedullary sites and significantly lower in the liver compared with the spleen. There was a "shift to the left" within the liver erythropoiesis and a significant megaloblastosis in the spleen. The same tendencies have formerly been found in patients with chronic myeloid leukemia and it is suggested that the discrepancies may be due to differences in the microenvironment of the erythropoietic cells.
对10例未经治疗的特发性骨髓纤维化（MF）患者的骨髓、脾脏和肝脏穿刺物进行了分析。脾脏和肝脏中幼红细胞的比例高于骨髓。在髓外部位，红细胞生成前体细胞的有丝分裂指数低于正常，且肝脏中的有丝分裂指数与脾脏相比显著更低。肝脏红细胞生成过程中出现了“左移”现象，脾脏中则有明显的巨幼细胞形成。此前在慢性髓性白血病患者中也发现了同样的趋势，提示这些差异可能是由于红细胞生成细胞微环境的不同所致。
