Laharrague P F, Cambus J P, Fillola G, Corberand J X
Service d'Hématologie, CHU Toulouse-Rangueil, France.
Aging (Milano). 1993 Dec;5(6):445-9. doi: 10.1007/BF03324200.
Results of prospective studies indicate that increased fibrinogen concentration is significantly associated with the risk of arteriosclerotic vessel disease. As the fibrinogen concentration is considered to rise with aging, determination of its physiological values with various methods in strictly healthy adult and aged individuals is a prerequisite to evaluating the relative contribution of fibrinogen to cardiovascular diseases. Fibrinogen concentration was determined in 209 healthy subjects, aged 19 to 96 years. Persons over the age of 60 were recruited according to the stringent criteria of the Senieur protocol established for human immunogerontological studies. Fibrinogen concentrations, obtained by heating precipitation and by thrombin clotting time with both electromagnetic water-bath and semiautomatic coagulometer, ranged from 1.55 to 3.70 g/L. A rise in plasma concentration was observed with aging. Independently of age, females exhibited higher concentrations than males. Significantly higher values were observed in subjects over 60 years of age, in both sexes, in comparison with the younger groups.
前瞻性研究结果表明，纤维蛋白原浓度升高与动脉硬化性血管疾病风险显著相关。由于纤维蛋白原浓度被认为会随着年龄增长而升高，因此在严格健康的成年人和老年人中用各种方法测定其生理值，是评估纤维蛋白原对心血管疾病相对贡献的前提条件。对209名年龄在19至96岁的健康受试者测定了纤维蛋白原浓度。60岁以上的人是根据为人体免疫老年学研究制定的严格的老年医学方案标准招募的。通过加热沉淀以及使用电磁水浴和半自动凝血仪的凝血酶凝血时间法测得的纤维蛋白原浓度范围为1.55至3.70 g/L。随着年龄增长，血浆浓度出现上升。与年龄无关，女性的纤维蛋白原浓度高于男性。与较年轻组相比，60岁以上的受试者无论男女，其纤维蛋白原浓度值均显著更高。
