Stulnig T, Mair A, Jarosch E, Schober M, Schönitzer D, Wick G, Huber L A
Institute for General and Experimental Pathology, University of Innsbruck, Austria.
Mech Ageing Dev. 1993 May;68(1-3):105-15. doi: 10.1016/0047-6374(93)90143-f.
Because many laboratory values change with age, the study of healthy aging as well as diagnosis of disease in geriatric patients requires specific age-corrected reference intervals. We have established such reference intervals for a healthy population aged 65-74 years by selection of a sample group applying the clinical criteria of the SENIEUR protocol and we have compared them with those of a young control group (20-33 years) fulfilling the same criteria. Significant or minor elevations were seen, e.g. for plasma concentrations of fasting glucose, urea, total and LDL-cholesterol, triglycerides, gamma-glutamyl-transferase, alkaline phosphatase, erythrocyte sedimentation rate and serum neopterin levels. These reference intervals can be used for selecting a SENIEUR compatible population aged between 65 and 74 years. Additionally, plasma lipid parameters (cholesterol, triglycerides) are proposed to be included in the SENIEUR protocol.
由于许多实验室检查值会随年龄变化，因此对健康衰老的研究以及老年患者疾病的诊断需要特定的年龄校正参考区间。我们通过选择一个应用SENIEUR方案临床标准的样本组，为65 - 74岁的健康人群建立了这样的参考区间，并将其与符合相同标准的年轻对照组（20 - 33岁）的参考区间进行了比较。发现了显著或轻微的升高，例如空腹血糖、尿素、总胆固醇和低密度脂蛋白胆固醇、甘油三酯、γ-谷氨酰转移酶、碱性磷酸酶、红细胞沉降率和血清新蝶呤水平的血浆浓度。这些参考区间可用于选择年龄在65至74岁之间符合SENIEUR标准的人群。此外，建议将血浆脂质参数（胆固醇、甘油三酯）纳入SENIEUR方案。
