Jamieson W R, Burr L H, Tyers G F, Munro A I
University of British Columbia, Vancouver, Canada.
J Heart Valve Dis. 1994 Jan;3(1):59-65.
From 1975 to 1986 the Carpentier-Edwards standard (CE-S) and supra-annular (CE-SAV) porcine bioprostheses were implanted in 1213 and 1000 patients, respectively. The mean age of the standard group was 57.6 years (range 8 to 85 years) while in the supra-annular group it was 60.7 years (range 13 to 85 years). The freedom from structural valve deterioration (SVD) at 10 years for the entire patient population was 79.4% +/- 3.1% with CE-SAV and 76.1% +/- 1.6% with CE-S (p < 0.05). The overall freedom from SVD for those patients undergoing mitral valve replacement (MVR) was 74.5% +/- 4.6% for CE-SAV and 68.7% +/- 2.8% for CE-S (p = NS), while for those undergoing aortic valve replacement (AVR) it was 86.5% +/- 4.3% for CE-SAV and 84.1% +/- 2.0% for CE-S (p = NS). In those patients under 35 years of age undergoing MVR, the freedom from SVD for CE-SAV and CE-S was 94.4% +/- 5.4% and 62.9% +/- 8.6%, respectively (p < 0.05 at 8 years); for those aged 36-50 years, it was 75.6% +/- 7.4% and 61.7% +/- 6.0%; for those aged 51-65 years, it was 76.2% +/- 7.4% and 69.6% +/- 4.2%; for those over 65 years, it was 74.1% +/- 7.1% and 82.2% +/- 5.2%; for those aged 65-69 years, it was 70.2% +/- 8.7% and 63.7% +/- 8.1%; and for those over 70 years of age, it was 79.2% +/- 8.7% and 95.3% +/- 3.2%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
1975年至1986年期间，分别有1213例和1000例患者植入了卡彭蒂埃 - 爱德华兹标准型（CE-S）和环上型（CE-SAV）猪生物瓣膜。标准型组患者的平均年龄为57.6岁（范围8至85岁），而环上型组为60.7岁（范围13至85岁）。整个患者群体在10年时无结构性瓣膜退变（SVD）的比例，CE-SAV为79.4%±3.1%，CE-S为76.1%±1.6%（p<0.05）。接受二尖瓣置换术（MVR）的患者中，CE-SAV无SVD的总体比例为74.5%±4.6%，CE-S为68.7%±2.8%（p=无显著差异）；接受主动脉瓣置换术（AVR）的患者中，CE-SAV为86.5%±4.3%，CE-S为84.1%±2.0%（p=无显著差异）。在年龄小于35岁接受MVR的患者中，CE-SAV和CE-S无SVD的比例分别为94.4%±5.4%和62.9%±8.6%（8年时p<0.05）；36至50岁的患者中，分别为75.6%±7.4%和61.7%±6.0%；51至65岁的患者中，分别为76.2%±7.4%和69.6%±4.2%；65岁以上的患者中，分别为74.1%±7.1%和82.2%±5.2%；65至69岁的患者中，分别为70.2%±8.7%和63.7%±8.1%；70岁以上的患者中，分别为79.2%±8.7%和95.3%±3.2%。（摘要截选至250字）
