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Rheumatoid factors and germline genes in rheumatoid arthritis: evidence of an intrinsic B-lymphocyte defect?

作者信息

Mageed R A, Vencovsky J, Maini R N

出版信息

Br J Rheumatol. 1994 Feb;33(2):105-7. doi: 10.1093/rheumatology/33.2.105.

DOI:10.1093/rheumatology/33.2.105
PMID:8162471
Abstract
摘要

相似文献

1
Rheumatoid factors and germline genes in rheumatoid arthritis: evidence of an intrinsic B-lymphocyte defect?类风湿关节炎中的类风湿因子和种系基因:存在内在B淋巴细胞缺陷的证据?
Br J Rheumatol. 1994 Feb;33(2):105-7. doi: 10.1093/rheumatology/33.2.105.
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The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidence that some autoantibodies are unmutated copies of germ line genes.从类风湿性关节炎患者滑膜组织中分离出的经爱泼斯坦-巴尔病毒转化的B细胞所产生的六种单特异性类风湿因子重链可变区的完整核苷酸序列。进一步证明某些自身抗体是种系基因的未突变拷贝。
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Rheumatoid factor V genes from patients with rheumatoid arthritis are diverse and show evidence of an antigen-driven response.类风湿性关节炎患者的类风湿因子V基因具有多样性,并显示出抗原驱动反应的证据。
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Immunoglobulin variable region (IgV) gene expression in rheumatoid factors from monozygotic twins with rheumatoid arthritis.
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The B lymphocyte in rheumatoid arthritis: analysis of rearranged V kappa genes from B cells infiltrating the synovial membrane.类风湿关节炎中的B淋巴细胞:对浸润滑膜的B细胞重排Vκ基因的分析。
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[Mutational pattern of Ig-VH genes of synovial B-lymphocytes from different anatomical locations in a rheumatoid arthritis patient].[类风湿关节炎患者不同解剖部位滑膜B淋巴细胞Ig-VH基因的突变模式]
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Nucleotide sequence analysis of rheumatoid factors and polyreactive antibodies derived from patients with rheumatoid arthritis reveals diverse use of VH and VL gene segments and extensive variability in CDR-3.
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V-gene repertoire and hypermutation of rheumatoid factors produced in rheumatoid synovial inflammation and immunized healthy donors.类风湿性滑膜炎和免疫健康供体中产生的类风湿因子的V基因库及超突变
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Eur J Immunol. 1991 May;21(5):1221-7. doi: 10.1002/eji.1830210519.

引用本文的文献

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Rheumatoid factor isotype switch and somatic mutation variants within rheumatoid arthritis synovium.类风湿关节炎滑膜内的类风湿因子同种型转换和体细胞突变变体。
Immunology. 1999 Sep;98(1):123-36. doi: 10.1046/j.1365-2567.1999.00841.x.
2
Serum immunoglobulins and the risk of rheumatoid arthritis.血清免疫球蛋白与类风湿关节炎风险
Ann Rheum Dis. 1997 Jun;56(6):351-6. doi: 10.1136/ard.56.6.351.
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Manual handling activities and risk of low back pain in nurses.护士的体力处理活动与腰痛风险
Occup Environ Med. 1995 Mar;52(3):160-3. doi: 10.1136/oem.52.3.160.