纳洛酮可拮抗乙醇诱导的小鼠睡眠，但不能拮抗γ-羟基丁酸诱导的小鼠睡眠。

Naloxone antagonizes ethanol- but not gamma-hydroxybutyrate-induced sleep in mice.

作者信息

Devoto P, Colombo G, Cappai F, Gessa G L

机构信息

Bernard B. Brodie Department of Neuroscience, University of Cagliari, Italy.

出版信息

Eur J Pharmacol. 1994 Feb 11;252(3):321-4. doi: 10.1016/0014-2999(94)90179-1.

DOI:10.1016/0014-2999(94)90179-1

PMID:8162953

Abstract

The present study examined the effect of naloxone on ethanol- and gamma-hydroxybutyric acid-induced narcosis in mice and the changes induced by these drugs on striatal dopamine metabolism. The results show that naloxone (1-10 mg/kg s.c.) markedly reduced ethanol-induced narcosis but failed to modify the duration of sleep induced by gamma-hydroxybutyrate. Naloxone (10 mg/kg) modified neither ethanol- nor gamma-hydroxybutyrate-induced changes in striatal dopamine and dihydroxyphenylacetic acid (DOPAC) content. The results suggest that gamma-hydroxybutyrate- and ethanol-induced narcosis are mediated by different mechanisms and that opioid receptors are not involved in the changes in dopamine metabolism induced by these compounds.

摘要

本研究考察了纳洛酮对乙醇和γ-羟基丁酸诱导的小鼠麻醉的影响，以及这些药物对纹状体多巴胺代谢的诱导变化。结果显示，纳洛酮（1-10毫克/千克，皮下注射）显著缩短了乙醇诱导的麻醉时间，但未能改变γ-羟基丁酸盐诱导的睡眠时间。纳洛酮（10毫克/千克）既未改变乙醇也未改变γ-羟基丁酸盐诱导的纹状体多巴胺和二羟基苯乙酸（DOPAC）含量的变化。结果表明，γ-羟基丁酸盐和乙醇诱导的麻醉是由不同机制介导的，且阿片受体不参与这些化合物诱导的多巴胺代谢变化。