Duclos D D, Jeffers J G, Shanley K J
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6010.
J Am Vet Med Assoc. 1994 Feb 15;204(4):616-9.
Medical records of 41 dogs with adult-onset generalized demodicosis diagnosed between 1979 and 1990 were reviewed. Of the 41 dogs, 8 had hyperadrenocorticism, 5 were suspected or confirmed to have hypothyroidism, 10 had allergic disease and had been treated with corticosteroids, and 6 were receiving chemotherapy because of a neoplastic or immune-mediated condition. In the remaining 12, a concurrent underlying condition was not identified. Thirty-four of the dogs were treated with amitraz dips: 7 were cured, 22 were clinically improved but still had Demodex canis mites in skin scrapings and needed amitraz dips on a maintenance basis, and 5 did not improve with treatment and were euthanatized. Of the 13 dogs with a definitively treatable underlying disease (hyperadrenocorticism or hypothyroidism), 9 were treated for the underlying disease and for demodicosis: 4 were cured, 3 were improved but still had D canis mites in skin scrapings and required maintenance amitraz dips, and 2 did not improve and were euthanatized. Of the 16 dogs that were receiving chemotherapy or had allergic disease, 15 were treated for the demodicosis while still receiving treatment for their underlying disease: 1 was cured, 13 were improved but needed maintenance amitraz dips, and 1 did not improve and was euthanatized. Of the 12 dogs without an identifiable underlying problem, 10 were treated: 2 were cured, 6 improved, but needed maintenance amitraz dips, and 2 did not improve and were euthanatized.
回顾了1979年至1990年间确诊为成年犬全身性蠕形螨病的41只犬的病历。在这41只犬中，8只患有肾上腺皮质功能亢进，5只疑似或确诊患有甲状腺功能减退，10只患有过敏性疾病并接受过皮质类固醇治疗，6只因肿瘤或免疫介导性疾病接受化疗。其余12只未发现并发的潜在疾病。34只犬接受了双甲脒药浴治疗：7只治愈，22只临床症状改善但皮肤刮片中仍有犬蠕形螨，需要持续进行双甲脒药浴，5只治疗后无改善，实施了安乐死。在13只患有可明确治疗的潜在疾病（肾上腺皮质功能亢进或甲状腺功能减退）的犬中，9只同时针对潜在疾病和蠕形螨病进行了治疗：4只治愈，3只改善但皮肤刮片中仍有犬蠕形螨，需要持续进行双甲脒药浴，2只无改善，实施了安乐死。在16只接受化疗或患有过敏性疾病的犬中，15只在接受基础疾病治疗的同时接受了蠕形螨病治疗：1只治愈，13只改善但需要持续进行双甲脒药浴，1只无改善，实施了安乐死。在12只未发现潜在问题的犬中，10只接受了治疗：2只治愈，6只改善但需要持续进行双甲脒药浴，2只无改善，实施了安乐死。
