Folz S D, Kratzer D D, Conklin R D, Nowakowski L H, Kakuk T J, Rector D L
Vet Parasitol. 1983 Aug;13(1):85-93. doi: 10.1016/0304-4017(83)90023-7.
Fifty-two dogs naturally parasitized with Demodex canis and having the generalized form of the disease were utilized to evaluate the efficacy and safety of single or multiple topical treatments with a liquid concentrate formulation of amitraz. Ten dogs (5 treated, 5 controls) were utilized to evaluate a single treatment. A single topical treatment with the miticide did not significantly reduce the incidence of dogs with mites, however, significant clinical improvement resulted. Side-effects were not observed after treatment. Forty-two dogs (26 treated, 16 controls) were utilized to evaluate multiple topical treatments with the liquid concentrate. A series of 3-6 treatments was applied topically at 14-day intervals. The dogs treated with the miticide received an average of 4.5 topical treatments. All (100%) of the dogs responded clinically, and the mean rate of improvement at four weeks post-treatment was 99.1%. Most dogs (96.2%) were cleared of mites after 3-6 treatments, and Mitaban did not cause any dermatologic, ocular, or other clinical side-effects. Multiple treatments with the liquid concentrate were highly efficacious and safe for treatment of generalized demodicosis. Control dogs did not improve clinically and retained mite populations.
52只自然感染犬蠕形螨且患有全身性疾病的犬被用于评估用双甲脒浓缩液制剂进行单次或多次局部治疗的疗效和安全性。10只犬（5只治疗，5只对照）用于评估单次治疗。用杀螨剂进行单次局部治疗并没有显著降低患螨犬的发病率，然而，却带来了显著的临床改善。治疗后未观察到副作用。42只犬（26只治疗，16只对照）用于评估用浓缩液进行多次局部治疗。每隔14天进行一系列3至6次局部治疗。用杀螨剂治疗的犬平均接受了4.5次局部治疗。所有（100%）犬都有临床反应，治疗后四周的平均改善率为99.1%。大多数犬（96.2%）在3至6次治疗后螨被清除，且双甲脒未引起任何皮肤、眼部或其他临床副作用。用浓缩液进行多次治疗对全身性蠕形螨病的治疗高度有效且安全。对照犬临床症状未改善且仍有螨寄生。
