Suárez A, Riestra S, Navascués C A, Sotorrío N G, Rodríguez M, Tévar F, Pérez R, Sala P, Rodrigo L
Seccion de Aparato Digestivo, Hospital de Covadonga.
Med Clin (Barc). 1994 Mar 12;102(9):329-32.
The aim of the present study was to know the current prevalence of HBsAg positivity in Asturias blood donors and to carry out a clinical study of the carriers of the hepatitis B virus (HBV) accidentally detected in a blood donation program.
A prospective study of incidence and prevalence of HBsAg positivity in blood donations performed in Asturias over two years from October 1989 and 1991 was carried out and the epidemiologic, clinical, and analytical characteristics, as well as histologic liver lesions in the HBsAg positive cases were determined.
Among the 42,789 blood donors during this above mentioned period in Asturias 119 cases of HBsAg positivity were found, representing a prevalence of 0.16% of the donations and 0.28% of the donors, generally new donors (95.8%) with a prevalence of 1.2% in this subgroup. No risk factors or known source of contagion were found in 43.6% of the cases and in most occasions the donors were asymptomatic HBsAg carriers (96.5%) with normal transaminases (87.3%) with 4.6% of the cases being HBeAg positive and 3.5% being mutant "e minus" carriers.
The prevalence of HBsAg was almost limited to new donors with a higher prevalence being observed with respect to other regions. Most of the cases may be considered as "apparently healthy" and in the group with positive replicative markers a similar number of positive HBeAg carriers and "e minus mutants" were present.
本研究旨在了解阿斯图里亚斯地区献血者中乙肝表面抗原（HBsAg）阳性的当前流行情况，并对在献血项目中意外检测出的乙型肝炎病毒（HBV）携带者进行临床研究。
对1989年10月至1991年两年间在阿斯图里亚斯进行的献血中HBsAg阳性的发病率和流行率进行了前瞻性研究，并确定了HBsAg阳性病例的流行病学、临床和分析特征以及肝脏组织学病变。
在上述阿斯图里亚斯地区的时间段内，42,789名献血者中发现了119例HBsAg阳性，占献血的0.16%，占献血者的0.28%，这些献血者通常是新献血者（95.8%），该亚组中的流行率为1.2%。43.6%的病例未发现危险因素或已知的传染来源，大多数情况下，献血者为无症状HBsAg携带者（96.5%），转氨酶正常（87.3%），4.6%的病例HBeAg阳性，3.5%为变异的“e阴性”携带者。
HBsAg的流行几乎仅限于新献血者，与其他地区相比，流行率更高。大多数病例可被视为“表面健康”，在具有阳性复制标志物的组中，HBeAg阳性携带者和“e阴性突变体”的数量相似。
