Myssiorek D, Vambutas A, Abramson A L
Department of Otolaryngology and Communicative Disorders, Long Island Jewish Medical Center, New Hyde Park, NY 11042.
Laryngoscope. 1994 Apr;104(4):463-7. doi: 10.1288/00005537-199404000-00011.
Carcinoma in situ (CIS) is part of the histopathologic spectrum of laryngeal disorders where invasive squamous cell carcinoma is the endpoint of cellular disarray. Few reports consider prognostic indicators that predict which lesions become invasive. Forty-one patients with CIS of the glottic larynx were analyzed for risk factors that would predict invasive cancer. Anterior commissure involvement by CIS resulted in 92% conversion to invasive squamous cell cancer compared to 17% of lesions limited to the mobile fold. Epidermal growth factor receptors were also analyzed and were found not to be helpful in predicting invasion. Lesions of the mobile fold should be removed endoscopically and the patient should be observed closely for recurrence. Anterior commissure involvement that is inaccessible to complete laser ablation should be radiated, and the patient should be observed carefully.
原位癌（CIS）是喉疾病组织病理学谱的一部分，其中浸润性鳞状细胞癌是细胞紊乱的终点。很少有报告考虑预测哪些病变会发生浸润的预后指标。对41例声门原位癌患者进行了分析，以寻找可预测浸润性癌的危险因素。声门原位癌累及前联合时，92%会转变为浸润性鳞状细胞癌，而局限于活动襞的病变这一比例为17%。还分析了表皮生长因子受体，发现其对预测浸润并无帮助。活动襞的病变应通过内镜切除，患者应密切观察有无复发。前联合受累且无法通过激光完全消融的应进行放疗，患者也应仔细观察。
