Castorina M, Ferraris L
Institute for Research on Senescence, Sigma-Tau, Pomezia, Rome, Italy.
Life Sci. 1994;54(17):1205-14. doi: 10.1016/0024-3205(94)00847-7.
Acetyl-L-carnitine (ALCAR), the acetyl ester of carnitine, is regarded as a compound of considerable interest because of its capacity to counteract several physiological and pathological modifications typical of brain ageing processes. In particular, it has been demonstrated that ALCAR can counteract the age-dependent reduction of several receptors in the central nervous system of rodents, such as the NMDA receptorial system, the Nerve Growth Factor (NGF) receptors, those of glucocorticoids, neurotransmitters and others, thereby enhancing the efficiency of synaptic transmission, which is considerably slowed down by ageing. The present review thus postulates the importance of ALCAR administration in preserving and/or facilitating the functionality of carnitines, the concentrations of which are diminished in the brain of old animals.
乙酰左旋肉碱（ALCAR）是肉碱的乙酰酯，因其能够对抗脑老化过程中典型的多种生理和病理变化而备受关注。特别是，已经证明ALCAR可以对抗啮齿动物中枢神经系统中多种受体随年龄增长而出现的减少，如N-甲基-D-天冬氨酸（NMDA）受体系统、神经生长因子（NGF）受体、糖皮质激素受体、神经递质受体等，从而提高突触传递效率，而突触传递效率会因衰老而显著减慢。因此，本综述假定给予ALCAR对于维持和/或促进肉碱的功能很重要，老龄动物大脑中肉碱的浓度会降低。
