Castorina M, Ambrosini A M, Pacific L, Ramacci M T, Angelucci L
Institute for Research on Senescence, Sigma Tau S.p.A., Pomezia, Italy.
Neurochem Res. 1994 Jul;19(7):795-8. doi: 10.1007/BF00967446.
Acute i.p. administration of Acetyl-L-Carnitine (ALCAR), a component of several biological systems, has been found to modify spontaneous and evoked electrocortical activity in young rats, and, in the old rats, to improve learning ability and to increase the number of NMDA receptors in the whole brain. The present study was aimed at ascertaining the effect of chronic treatment with ALCAR added to drinking water on age-related changes in the different brain areas of rats. In twenty-four-month-old rats, ALCAR treatment for six months significantly impeded the decline in the number of NMDA receptors within the hippocampus, the frontal cortex and the striatum compared to the adult animal. This finding thus confirms the previously reported positive effect of ALCAR on the brain NMDA receptor system.
急性腹腔注射乙酰左旋肉碱（ALCAR），它是多种生物系统的组成成分，已被发现可改变幼鼠的自发和诱发皮质电活动，并且在老年大鼠中，可提高学习能力并增加全脑NMDA受体的数量。本研究旨在确定在饮用水中添加ALCAR进行长期治疗对大鼠不同脑区与年龄相关变化的影响。与成年动物相比，对24个月大的大鼠进行6个月的ALCAR治疗可显著阻碍海马体、额叶皮质和纹状体中NMDA受体数量的下降。这一发现因此证实了先前报道的ALCAR对脑NMDA受体系统的积极作用。
