Bethlenfalvay N C, Henley L B, Rupp T D, Phyliky R L
Cancer. 1976 Mar;37(3):1449-55. doi: 10.1002/1097-0142(197603)37:3<1449::aid-cncr2820370328>3.0.co;2-2.
Twenty-three years after an injection of Thorotrast, profound depression of humoral and cellular immunity associated with extensive marrow plasmocytosis developed in a man aged 75 years. Twelve months of chemotherapy with L-phenylalanine mustard, resulted in hematologic remission. Radioautograph of his marrow showed signs of alpha-radiation; whole body counting revealed a significant thorium burden. One year after chemotherapy was stopped, and two years after initial presentation, aleukemic acute granulocytic leukemia led to his death. The role of thorium in the etiology of possibly two successive hematopoietic neoplasms is discussed.
在注射钍造影剂23年后，一名75岁男性出现了体液和细胞免疫的严重抑制，并伴有广泛的骨髓浆细胞增多症。用左旋苯丙氨酸氮芥进行了12个月的化疗，实现了血液学缓解。他骨髓的放射自显影片显示出α辐射的迹象；全身计数显示钍负荷显著。化疗停止一年后，即初次就诊两年后，无白血病的急性粒细胞白血病导致了他的死亡。本文讨论了钍在可能的两种连续造血系统肿瘤病因中的作用。
