Baker P N, Hackett G A
Department of Obstetrics and Gynaecology, University of Nottingham, United Kingdom.
Obstet Gynecol. 1994 May;83(5 Pt 1):745-9.
To assess the potential of both urinary albumin creatinine ratios and urinary calcium-creatinine ratios as screening tests for pregnancy-induced hypertension.
A prospective, non-interventional study was performed in a teaching hospital antenatal clinic. Five hundred normotensive, nulliparous pregnant women provided a urine sample at 19 weeks' gestation. The main outcome measurements were the development of pregnancy-induced hypertension and preeclampsia.
No significant differences in urinary albumin/creatinine and calcium/creatinine were demonstrated between patients who developed pregnancy-induced hypertension and those who remained normotensive. Urinary creatinine concentrations were significantly higher at 19 weeks' gestation in patients who subsequently developed pregnancy-induced hypertension.
This study suggests that neither urinary ratio is a potential screening test for pregnancy-induced hypertension. The increased urinary creatinine concentration in patients who subsequently developed pregnancy-induced hypertension has not previously been reported and merits further investigation.
评估尿白蛋白肌酐比值和尿钙肌酐比值作为妊娠高血压筛查试验的潜力。
在一家教学医院的产前诊所进行了一项前瞻性、非干预性研究。500名血压正常的初产妇在妊娠19周时提供了一份尿液样本。主要观察指标为妊娠高血压和子痫前期的发生情况。
发生妊娠高血压的患者与血压仍正常的患者之间，尿白蛋白/肌酐和钙/肌酐无显著差异。随后发生妊娠高血压的患者在妊娠19周时尿肌酐浓度显著更高。
本研究表明，这两种尿比值均不是妊娠高血压的潜在筛查试验。随后发生妊娠高血压的患者尿肌酐浓度升高此前未见报道，值得进一步研究。
