Sirohiwal Daya, Dahiya Krishna, Khaneja Neha
Department of Obstetrics and Gynecology, Pandit Bhagwat Dayal Sharma, Post-Graduate Institute of Medical Sciences, Rohtak, India.
Taiwan J Obstet Gynecol. 2009 Jun;48(2):113-5. doi: 10.1016/S1028-4559(09)60268-0.
To assess the efficacy of 24-hour urinary protein and calcium for the prediction of preeclampsia.
Two hundred normotensive women at 20-28 weeks' gestation were enrolled in the study. All women were asked to collect a 24-hour urine sample. Urinary protein and calcium were measured and expressed as milligrams per 24 hours. Sensitivity, specificity and predictive values were calculated for each test, and cutoff values were calculated using receiver operating characteristic curves.
Twenty-one of the 200 women developed preeclampsia, including eight who developed severe preeclampsia and 13 who developed mild preeclampsia. Compared with the normotensive women (n = 179), the hypertensive patients (n = 21) had significantly lower urinary calcium excretion (167.23 +/- 80.63 mg vs. 277.43 +/- 60.38 mg) and higher proteinuria (351.14 +/- 41.58 mg vs. 296.33 +/- 30.03 mg).
A decrease in 24-hour urinary calcium and increase in protein between 20-28 weeks' gestation are risk factors for preeclampsia.
评估24小时尿蛋白和钙对预测子痫前期的有效性。
招募200名妊娠20 - 28周的血压正常女性参与研究。所有女性均被要求收集24小时尿液样本。测量尿蛋白和钙，并以每24小时毫克数表示。计算每项检测的敏感性、特异性和预测值，并使用受试者工作特征曲线计算临界值。
200名女性中有21名发生子痫前期，其中8名发生重度子痫前期，13名发生轻度子痫前期。与血压正常女性（n = 179）相比，高血压患者（n = 21）的尿钙排泄量显著降低（167.23±80.63毫克对277.43±60.38毫克），蛋白尿更高（351.14±41.58毫克对296.33±30.03毫克）。
妊娠20 - 28周期间24小时尿钙降低和蛋白增加是子痫前期的危险因素。
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