Babichev V N, Adamskaia E I, Peryshkova T A
Probl Endokrinol (Mosk). 1994 Jan-Feb;40(1):43-6.
In vitro insulin effect on basal and LH-RH-stimulated gonadotropin secretion in oophorectomized female rats with streptozotocin diabetes administered estradiol as replacing hormone therapy was studied. The results were compared to those obtained after a similar incubation of adenohypophyses of oophorectomized rats and of oophorectomized rats administered estradiol. Estradiol was found to change the type of LH-RH-stimulated gonadotropin secretion in oophorectomized animals. Basal, but not LH-RH-stimulated gonadotropin secretion, was increased in rats with experimental diabetes as against other groups. Insulin inhibited basal and increased LH-RH-stimulated gonadotropin secretion in oophorectomized rats with streptozotocin diabetes administered estradiol. A conclusion is made about impaired sensitivity of hypophyseal gonadotrophs to LH-RH in streptozotocin diabetes and about a possible contribution of insulin to regulation of body reproductive system at the level of hypophysis.
研究了在切除卵巢的雌性大鼠中，体外胰岛素对给予雌二醇作为替代激素疗法的链脲佐菌素糖尿病大鼠基础及促性腺激素释放激素（LH-RH）刺激的促性腺激素分泌的影响。将结果与切除卵巢的大鼠及给予雌二醇的切除卵巢大鼠的腺垂体进行类似孵育后获得的结果进行了比较。发现雌二醇改变了切除卵巢动物中LH-RH刺激的促性腺激素分泌类型。与其他组相比，实验性糖尿病大鼠的基础促性腺激素分泌增加，但LH-RH刺激的促性腺激素分泌未增加。胰岛素抑制了给予雌二醇的链脲佐菌素糖尿病切除卵巢大鼠的基础促性腺激素分泌，并增加了LH-RH刺激的促性腺激素分泌。得出结论：链脲佐菌素糖尿病中垂体促性腺细胞对LH-RH的敏感性受损，并且胰岛素可能在垂体水平对机体生殖系统的调节起作用。
