Wallnöfer A E, van Griensven J M, Schoemaker H C, Cohen A F, Lambert W, Kluft C, Meijer P, Kooistra T
Centre for Human Drug Research, University Hospital Leiden, The Netherlands.
Thromb Haemost. 1993 Dec 20;70(6):1005-8.
The effect of isotretinoin on fibrinolysis was investigated in 10 healthy, male volunteers in a randomized, double-blind, crossover-designed study. Isotretinoin (40 mg) was administered in the morning and in the evening for 5 days. t-PA, u-PA and PAI-1 antigen and activity in plasma were measured every morning at 9 a.m. on days 1 to 4 and every 3 hours over 24 hours on day 5. Isotretinoin treatment had no significant stimulatory effect on endogenous t-PA antigen and activity in morning plasma samples nor on their circadian variation. Also, u-PA antigen levels did not change after isotretinoin treatment. Mean PAI-1 antigen and PAI activity in 9 a.m. plasma samples were non-significantly higher during isotretinoin than during placebo treatment. After treatment with isotretinoin a significant rise of fasting triglyceride plasma levels was observed as compared to placebo. The study shows that isotretinoin has no clinically significant effect on endogenous fibrinolysis.
在一项随机、双盲、交叉设计的研究中，对10名健康男性志愿者研究了异维甲酸对纤维蛋白溶解的影响。异维甲酸（40毫克）早晚各服用一次，共服用5天。在第1至4天每天上午9点测量血浆中组织型纤溶酶原激活物（t-PA）、尿激酶型纤溶酶原激活物（u-PA）和纤溶酶原激活物抑制剂-1（PAI-1）的抗原和活性，在第5天24小时内每3小时测量一次。异维甲酸治疗对早晨血浆样本中内源性t-PA抗原和活性及其昼夜变化均无显著刺激作用。此外，异维甲酸治疗后u-PA抗原水平没有变化。与安慰剂治疗期间相比，异维甲酸治疗期间上午9点血浆样本中的平均PAI-1抗原和PAI活性略高，但无统计学意义。与安慰剂相比，异维甲酸治疗后空腹血浆甘油三酯水平显著升高。该研究表明，异维甲酸对内源性纤维蛋白溶解无临床显著影响。
