Davis F B, Estruch M T, Samson-Corvera E B, Voigt G C, Tobin J D
Compr Ther. 1975 Dec;1(8):65-9.
The Anticoagulation Service insures uniformity of approach to the regulation of anticoagulation for patients of hospital-based primary physicians. There has been no anticoagulant-related mortality in 254 patient treatment-years, and the major complication rate is 4% of treatment courses. There is a relatively low complication rate because of the systematic approach to anticoagulation therapy, recognition of the importance of patient education, communication with the primary physician, and flexibility of drug dosage and patient visit regimens. Achieving the therapeutic range of the prothrombin time with minimum complications is the goal of this Service. The hallmark of adequate control is predictable response of the prothrombin time to adjustments in drug dosage. Statistical analysis of six years' experience has provided support for the thesis that control of anticoagulation and incidence of complications are not significantly altered by patient age, sex, or the presence of concurrent nonthromboembolic medical illness.
抗凝服务确保了医院基层医生对患者进行抗凝治疗的方法具有一致性。在254个患者治疗年中未发生与抗凝剂相关的死亡病例，主要并发症发生率为治疗疗程的4%。由于采用了系统的抗凝治疗方法、认识到患者教育的重要性、与基层医生进行沟通以及药物剂量和患者就诊方案的灵活性，并发症发生率相对较低。以最小的并发症达到凝血酶原时间的治疗范围是该服务的目标。充分控制的标志是凝血酶原时间对药物剂量调整有可预测的反应。对六年经验的统计分析支持了以下论点：患者的年龄、性别或同时存在的非血栓栓塞性内科疾病对抗凝控制和并发症发生率没有显著影响。
