Poli Daniela, Antonucci Emilia, Lombardi Alessandra, Cecchi Emanuele, Corsini Isabella, Gensini Gian Franco, Abbate Rosanna, Prisco Domenico
Thrombosis Center, Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy.
Ital Heart J. 2003 Jan;4(1):44-7.
Over the last years, the use of oral anticoagulant treatment (OAT) has increased dramatically, principally for the prevention of embolic stroke in patients with atrial fibrillation. This study was aimed at evaluating the efficacy and safety of the management of OAT in a real-practice situation.
Nine hundred and three consecutive unselected patients, 250 of whom with atrial fibrillation, referred for the control of OAT to the Anticoagulation Clinic of the University of Florence were studied. The total follow-up period was 1679 patient-years.
The rate of major bleeding events was 0.8 per 100 patient-years in atrial fibrillation patients. In patients with a target INR > or = 3 a significantly higher rate of bleeding (p = 0.02) with respect to patients with a target INR < 3 was observed.
A low incidence of complications may be obtained even in elderly atrial fibrillation patients on OAT followed in an Anticoagulation Clinic specifically devoted to this management.
在过去几年中，口服抗凝治疗（OAT）的使用显著增加，主要用于预防心房颤动患者的栓塞性中风。本研究旨在评估实际临床情况下OAT管理的有效性和安全性。
对连续903例未经选择的患者进行了研究，其中250例患有心房颤动，他们因OAT控制而被转诊至佛罗伦萨大学抗凝门诊。总随访期为1679患者年。
心房颤动患者的主要出血事件发生率为每100患者年0.8例。与目标国际标准化比值（INR）<3的患者相比，目标INR≥3的患者出血率显著更高（p = 0.02）。
即使在专门进行此类管理的抗凝门诊对接受OAT治疗的老年心房颤动患者进行随访，并发症的发生率也可能较低。
