Rosenthal J, Ben Arush M W, Kuten A, Ben Arie J, Ben Shahar M, Robinson E
Pediatric Oncology Unit, Rambam Medical Center, Haifa, Israel.
Am J Pediatr Hematol Oncol. 1994 May;16(2):138-42.
A retrospective analysis of Hodgkin's disease (HD) in children treated at the Northern Israel Cancer Center between 1971 and 1990 was conducted.
Records of 102 patients < 18 years of age at diagnosis were reviewed. Patient characteristics were similar to those previously reported. There were 54 boys and 48 girls (1.1:1 boy:girl ratio), with more boys < 10 years of age. Forty-four patients were of Arab ancestry and 58 were Jewish; incidence rates were similar in both groups. The most common histological types were nodular sclerosing and mixed cellularity, the latter being more commonly diagnosed in the younger age group.
The outcome of various treatment modalities in childhood HD were evaluated. Sixty-five patients (64%) had stage I or II and 37 (34%) had stage III or IV at diagnosis. Patients with stage I-II received radiotherapy alone (20 patients), chemotherapy alone (10 patients), or a combined approach of chemotherapy plus radiotherapy (35 patients). Survival rates and median disease-free intervals were statistically similar in all three modalities. However, relapse rates were higher among patients receiving radiotherapy alone or chemotherapy alone (35% and 38%, respectively) compared with patients receiving chemotherapy plus radiotherapy (14%).
We conclude that a combined approach of chemotherapy plus radiotherapy is advantageous over radiotherapy alone or chemotherapy alone.
对1971年至1990年间在以色列北部癌症中心接受治疗的儿童霍奇金淋巴瘤（HD）进行回顾性分析。
回顾了102例诊断时年龄小于18岁患者的记录。患者特征与先前报道的相似。有54名男孩和48名女孩（男女比例为1.1:1），10岁以下男孩更多。44例患者为阿拉伯裔，58例为犹太裔；两组发病率相似。最常见的组织学类型为结节硬化型和混合细胞型，后者在较年轻年龄组中更常见。
评估了儿童HD各种治疗方式的结果。65例患者（64%）诊断时为I期或II期，37例（34%）为III期或IV期。I-II期患者接受单纯放疗（20例）、单纯化疗（10例）或化疗加放疗联合治疗（35例）。三种治疗方式的生存率和无病间期中位数在统计学上相似。然而，单纯接受放疗或单纯化疗的患者复发率较高（分别为35%和38%），而接受化疗加放疗的患者复发率为14%。
我们得出结论，化疗加放疗联合治疗比单纯放疗或单纯化疗更具优势。
