Ben-Arush M, Rosenthal J, Peretz-Nahum M, Kuten A, Ben-Arie J, Ben Shahar B, Yarom J, Robinson E
Northern Israel Cancer Center, Pathology Dept., Rambam Medical Center, Haifa.
Harefuah. 1993 Nov 15;125(10):333-7, 392.
Records of children treated for Hodgkin's disease between 1971-1990 were analyzed retrospectively, and 102 cases of children younger than 18 years when diagnosed were reviewed. There were 54 boys and 48 girls, with male predominance in those younger than 10 years. 44 patients were of Arab ancestry and 58 were Jewish; the incidence was similar in both groups. Most common were the nodular sclerosing and mixed cellularity types, the latter more common in the younger age group. The outcome of various treatments was evaluated. At diagnosis, 64% were in stages I or II and 34% in stages III or IV. 20 of those in stages I-II received radiotherapy (RT) alone, 10 chemotherapy (CT) alone, and 35 combined CT and RT. Survival rates and median disease-free intervals were statistically similar with all 3 modalities. However, relapse rates were higher with either RT or CT alone (35% and 38%, respectively) than with combined therapy (14%). We conclude that combined CT and RT is superior to RT or CT alone.
对1971年至1990年间接受霍奇金病治疗的儿童记录进行回顾性分析，对确诊时年龄小于18岁的102例儿童病例进行了复查。有54名男孩和48名女孩，10岁以下儿童中男性占优势。44例患者为阿拉伯血统，58例为犹太血统；两组发病率相似。最常见的是结节硬化型和混合细胞型，后者在较年轻年龄组中更常见。评估了各种治疗的结果。诊断时，64%处于I期或II期，34%处于III期或IV期。I-II期患者中，20例仅接受放疗（RT），10例仅接受化疗（CT），35例接受CT与RT联合治疗。所有三种治疗方式的生存率和无病间隔中位数在统计学上相似。然而，单独使用RT或CT的复发率（分别为35%和38%）高于联合治疗（14%）。我们得出结论，CT与RT联合治疗优于单独的RT或CT。
