Béné M C, Faure G C
Laboratoire d'immunologie, faculté de médecine et CHU de Nancy, Vandoeuvre-les-Nancy, France.
Ann Biol Clin (Paris). 1993;51(9):793-800.
The increasing availability of reagents and technologies has resulted in the widespread use of immunophenotyping to define and assess the course of pathologic disorders involving lymphoid cells. The diversity of markers and of the disorders concerned has complicated the application of the technique. This paper reviews lymphocyte differentiation antigens, the technologies available to study them and possible applications in immunopathology. Four major disease groups are discussed: spontaneous immunodeficiencies, iatrogenic immunodeficiencies, auto-immune disorders and lymphoproliferative diseases. The importance of sequential explorations is stressed, where the abnormalities observed are analysed in the dynamic context of the disease and its therapy.
试剂和技术日益普及，使得免疫表型分析得以广泛应用于定义和评估涉及淋巴细胞的病理疾病进程。相关标志物和疾病的多样性使该技术的应用变得复杂。本文综述了淋巴细胞分化抗原、研究这些抗原的可用技术以及在免疫病理学中的可能应用。讨论了四大类疾病：自发性免疫缺陷、医源性免疫缺陷、自身免疫性疾病和淋巴增殖性疾病。强调了序贯检测的重要性，即在疾病及其治疗的动态背景下分析所观察到的异常情况。
