曲拉通WR1339和去唾液酸胎球蛋白对肝脏摄取循环中的天然和去唾液酸癌胚抗原的影响。
The effects of triton WR1339 and asialo-fetuin on the hepatic uptake of circulating native and asialo-carcinoembryonic antigen.
作者信息
Thomas P, Jones M
出版信息
Biochem J. 1978 Sep 1;173(3):981-3. doi: 10.1042/bj1730981.
Abstract
Uptake of carcinoembryonic antigen from the circulation of the mouse is inhibited by treatment of the animal with Triton WR1339, but not by asialo-fetuin. Uptake of asialo-carcinoembryonic antigen is inhibited by asialo-fetuin, but not by Triton WR1339. These results reflect the different mechanisms of uptake of the glycoproteins. The presence or absence of sialic acid does not seem to be important in governing Kupffer-cell uptake, but when terminal galactoses are exposed on a glycoprotein, uptake by hepatocytes is preferred. Kupffer-cell uptake of carcinoembryonic antigen is not due to the formation of high-molecular-weight complexes in the blood stream. The effect of asialo-fetuin and Triton WR1339 on the biliary excretion of carcinoembryonic antigen and asialo-carcinoembryonic antigen is discussed.
摘要
用曲拉通WR1339处理小鼠可抑制其循环系统中癌胚抗原的摄取，但脱唾液酸胎球蛋白无此作用。脱唾液酸癌胚抗原的摄取可被脱唾液酸胎球蛋白抑制，但不受曲拉通WR1339影响。这些结果反映了糖蛋白摄取的不同机制。唾液酸的存在与否似乎对库普弗细胞的摄取并不重要，但当糖蛋白上的末端半乳糖暴露时，肝细胞更倾向于摄取。库普弗细胞对癌胚抗原的摄取并非由于血流中形成高分子量复合物所致。文中还讨论了脱唾液酸胎球蛋白和曲拉通WR1339对癌胚抗原和脱唾液酸癌胚抗原胆汁排泄的影响。
相似文献
1
The effects of triton WR1339 and asialo-fetuin on the hepatic uptake of circulating native and asialo-carcinoembryonic antigen.曲拉通WR1339和去唾液酸胎球蛋白对肝脏摄取循环中的天然和去唾液酸癌胚抗原的影响。
Biochem J. 1978 Sep 1;173(3):981-3. doi: 10.1042/bj1730981.
2
Studies on the mechanisms of biliary excretion of circulating glycoproteins. The carcinoembryonic antigen.循环糖蛋白的胆汁排泄机制研究。癌胚抗原。
Biochem J. 1980 Dec 15;192(3):837-43. doi: 10.1042/bj1920837.
3
Uptake and degradation of asialo-fetuin by isolated rat hepatocytes.离体大鼠肝细胞对去唾液酸胎球蛋白的摄取与降解
Acta Biol Med Ger. 1977;36(11-12):1753-62.
4
Uptake and degradation of 125I-labelled asialo-fetuin by isolated rat hepatocytes.分离的大鼠肝细胞对125I标记的去唾液酸胎球蛋白的摄取与降解
Biochim Biophys Acta. 1977 Aug 25;499(1):73-84. doi: 10.1016/0304-4165(77)90230-6.
5
Binding of concanavalin A to isolated hepatocytes and its effect on uptake and degradation of asialo-fetuin by the cells.伴刀豆球蛋白A与分离的肝细胞的结合及其对细胞摄取和降解去唾液酸胎球蛋白的影响。
Biochem J. 1980 Sep 15;190(3):697-703. doi: 10.1042/bj1900697.
6
Investigation of the uptake of asialo-glycoproteins by isolated rat hepatocytes. Implications for its biological significance.对分离的大鼠肝细胞摄取去唾液酸糖蛋白的研究及其生物学意义
Hoppe Seylers Z Physiol Chem. 1980 Aug;361(8):1155-64. doi: 10.1515/bchm2.1980.361.2.1155.
7
Glycoprotein catabolism in rat liver: Lysosomal digestion of iodinated asialo-fetuin.大鼠肝脏中的糖蛋白分解代谢：碘化去唾液酸胎球蛋白的溶酶体消化
Biochem J. 1975 Nov;152(2):271-9. doi: 10.1042/bj1520271.
8
Intracellular segregation of asialo-transferrin and asialo-fetuin following uptake by the same receptor system in suspended hepatocytes.去唾液酸转铁蛋白和去唾液酸胎球蛋白在悬浮肝细胞中通过同一受体系统摄取后的细胞内分隔
Biochim Biophys Acta. 1984 Mar 23;803(3):182-90. doi: 10.1016/0167-4889(84)90008-9.
9
The mechanism of biliary excretion of alpha 1-acid glycoprotein in the rat: evidence for a molecular weight-dependent, nonreceptor-mediated pathway.大鼠体内α1-酸性糖蛋白的胆汁排泄机制：分子量依赖性非受体介导途径的证据。
Hepatology. 1982 Nov-Dec;2(6):800-3. doi: 10.1002/hep.1840020610.
引用本文的文献
1
A new Kupffer cell receptor mediating plasma clearance of carcinoembryonic antigen by the rat.一种介导大鼠清除癌胚抗原血浆的新型库普弗细胞受体。
Biochem J. 1982 May 15;204(2):377-81. doi: 10.1042/bj2040377.
2
Role of the liver in clearance and excretion of circulating carcinoembryonic antigen (CEA).肝脏在循环癌胚抗原（CEA）清除和排泄中的作用。
Dig Dis Sci. 1983 Mar;28(3):216-24. doi: 10.1007/BF01295116.
3
Studies on the mechanisms of biliary excretion of circulating glycoproteins. The carcinoembryonic antigen.循环糖蛋白的胆汁排泄机制研究。癌胚抗原。
Biochem J. 1980 Dec 15;192(3):837-43. doi: 10.1042/bj1920837.
4
Serum beta-N-acetyl hexosaminidase and bile acid levels in patients with benign and malignant biliary obstruction.良性和恶性胆道梗阻患者的血清β-N-乙酰己糖胺酶和胆汁酸水平
Dig Dis Sci. 1988 Feb;33(2):189-92. doi: 10.1007/BF01535732.
5
Identification of a defence mechanism in vivo against the leakage of enterokinase into the blood.体内针对肠激酶漏入血液的防御机制的鉴定。
Biochem J. 1979 Dec 15;184(3):619-26. doi: 10.1042/bj1840619.
本文引用的文献
1
The thiobarbituric acid assay of sialic acids.唾液酸的硫代巴比妥酸测定法。
J Biol Chem. 1959 Aug;234(8):1971-5.
2
Role of plasma carcinoembryonic antigen in diagnosis of gastrointestinal, mammary, and bronchial carcinoma.血浆癌胚抗原在胃肠道、乳腺癌和支气管癌诊断中的作用。
Br Med J. 1972 Sep 9;3(5827):605-9. doi: 10.1136/bmj.3.5827.605.
3
The preparation of purified carcinoembryonic antigen of the human digestive system from large quantities of tumor tissue.从大量肿瘤组织中制备人消化系统纯化癌胚抗原。
Immunochemistry. 1972 Jun;9(6):617-22. doi: 10.1016/0019-2791(72)90247-9.
4
Mechanisms of enhanced intrahepatic metastasis in surfactant-treated hamsters: an electron microscopy study.
Int J Cancer. 1973 May;11(3):725-38. doi: 10.1002/ijc.2910110324.
5
The role of surface carbohydrates in the hepatic recognition and transport of circulating glycoproteins.表面碳水化合物在肝脏对循环糖蛋白的识别和转运中的作用。
Adv Enzymol Relat Areas Mol Biol. 1974;41(0):99-128. doi: 10.1002/9780470122860.ch3.
6
Studies on the structure of the carcinoembryonic antigen. I. some deductions on the basis of chemical degradations.癌胚抗原结构的研究。I. 基于化学降解的一些推断。
Immunochemistry. 1974 Dec;11(12):811-8. doi: 10.1016/0019-2791(74)90302-4.
7
The existence of a second route for the transfer of certain glycoproteins from the circulation into the liver.存在一条将某些糖蛋白从循环系统转运至肝脏的第二条途径。
Biochem Biophys Res Commun. 1976 Feb 9;68(3):988-93. doi: 10.1016/0006-291x(76)91243-2.
8
The hepatic clearance of circulating native and asialo carcinoembronic antigen by the rat.大鼠对循环中的天然和去唾液酸癌胚抗原的肝脏清除率。
Biochem Biophys Res Commun. 1975 Dec 1;67(3):1205-9. doi: 10.1016/0006-291x(75)90801-3.
9
A radioautographic study of the hepatic uptake of circulating carcinoembryonic antigen by the mouse.小鼠肝脏对循环癌胚抗原摄取的放射自显影研究。
Biochem Soc Trans. 1977;5(1):312-3. doi: 10.1042/bst0050312.
10
A shorter immunoperoxidase technique for the demonstration of carcinoembryonic antigen and other cell products.一种用于显示癌胚抗原及其他细胞产物的更短免疫过氧化物酶技术。
J Clin Pathol. 1977 Feb;30(2):138-40. doi: 10.1136/jcp.30.2.138.
Zotero 插件