Leslie G A
Immunol Commun. 1975;4(6):529-36. doi: 10.3109/08820137509055791.
Chickens bursectomized at hatch and/or treated with anti-immunoglobulin reagents such as anti-mu, anti-upsilon and F(ab')2 anti-mu may become agammaglobulinemic, hypogammaglobulinemic, hypergammaglobulinemic or exhibit normal levels of immunoglobulins. IgM and IgY produced by these dysgammaglobulinemic chickens were demonstrated to be polyclonal in origin. The IgM from chickens with hyper-IgM-globulinemia is also polyclonal in origin unlike the situation seen in Waldenstrom's macroglobulinemia. These data do not rule out restricted allotype or subclass expression.
在孵化时进行法氏囊切除和/或用抗免疫球蛋白试剂（如抗μ、抗υ和F(ab')2抗μ）处理的鸡，可能会出现无丙种球蛋白血症、低丙种球蛋白血症、高丙种球蛋白血症或表现出正常水平的免疫球蛋白。这些丙种球蛋白异常血症鸡产生的IgM和IgY被证明是多克隆起源的。与瓦尔登斯特伦巨球蛋白血症的情况不同，高IgM球蛋白血症鸡的IgM也是多克隆起源的。这些数据并不排除有限的同种异型或亚类表达。
