Sladek F M
University of California, Riverside 92521.
Receptor. 1993 Fall;3(3):223-32.
Hepatocyte nuclear factor 4 (HNF-4), found in liver, kidney, and intestine, is a potent transcriptional activator that controls the expression of a wide variety of genes, including those involved in fatty acid and cholesterol metabolism, glucose metabolism, urea biosynthesis, blood coagulation, hepatitis B infections, and liver differentiation. HNF-4 is also a member of the steroid hormone receptor superfamily and has been highly conserved throughout evolution, suggesting that it might respond to an as yet unidentified ligand. In this presentation, some of the current findings regarding the role of HNF-4 in liver-specific gene expression are reviewed.
肝细胞核因子4（HNF - 4）存在于肝脏、肾脏和肠道中，是一种强大的转录激活因子，可控制多种基因的表达，包括那些参与脂肪酸和胆固醇代谢、葡萄糖代谢、尿素生物合成、血液凝固、乙型肝炎感染及肝脏分化的基因。HNF - 4也是类固醇激素受体超家族的成员，在整个进化过程中高度保守，这表明它可能对一种尚未确定的配体作出反应。在本报告中，将对目前有关HNF - 4在肝脏特异性基因表达中作用的一些研究结果进行综述。
