在含有胎牛血清的培养基中生长的大鼠肝上皮细胞的表面抗原。
Surface antigens of rat liver epithelial cells grown in medium containing foetal bovine serum.
作者信息
Embleton M J, Iype P T
出版信息
Br J Cancer. 1978 Sep;38(3):456-60. doi: 10.1038/bjc.1978.229.
Abstract
Cultured rat liver cells induced a strong antibody response in syngeneic rats, directed against foetal calf serum components which were incorporated into the liver cell surface from the cell-culture medium. This antibody could be removed by absorption with liver cells or glutaraldehyde-fixed foetal calf serum. It is possible that the antigenic cross-reactivity observed in earlier studies with cultured cells treated with carcinogens could be due to this foetal calf serum component.
摘要
培养的大鼠肝细胞在同基因大鼠中诱导出强烈的抗体反应，该反应针对的是从细胞培养基掺入肝细胞表面的胎牛血清成分。这种抗体可以通过与肝细胞或戊二醛固定的胎牛血清吸收而去除。早期对用致癌物处理的培养细胞进行的研究中观察到的抗原交叉反应，可能是由于这种胎牛血清成分所致。
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