有和没有子宫内膜异位症时输卵管前列腺素的产生
Fallopian tube prostaglandin production with and without endometriosis.
作者信息
Nabekura H, Koike H, Ohtsuka T, Yamaguchi M, Miyakawa I, Mori N
机构信息
Department of Obstetrics and Gynecology, Miyazaki Medical College, Japan.
出版信息
Int J Fertil Menopausal Stud. 1994 Jan-Feb;39(1):57-63.
OBJECTIVE
To investigate the potential role of prostaglandins (PGs) in tubal function in endometriosis.
SUBJECTS
Fallopian tubes were obtained from 36 women undergoing abdominal total hysterectomy.
METHODS
PG production of the human fallopian tube was measured by radioimmunoassay.
RESULTS
In normal controls, ampulla and fimbriae in the proliferative and secretory phases produced more PGE and PGF than isthmus. PGE production in ampulla and fimbriae increased in proliferative and secretory phases. PGF production was predominant in the proliferative phase in all parts. There was no significant cyclic or regional variation in 6-keto-PGF1 alpha and thromboxane B2 production.
CONCLUSIONS
In patients with endometriosis, isthmus and ampulla produced much more PGE and PGF in the proliferative phase than normal controls. The variation of PGF/PGE ratio in endometriosis was different from that of normal controls. It was apparent that tubal PG production is altered in endometriosis.
目的
探讨前列腺素（PGs）在子宫内膜异位症输卵管功能中的潜在作用。
研究对象
从36例行腹式全子宫切除术的女性获取输卵管。
方法
采用放射免疫分析法测定人输卵管的PG生成量。
结果
在正常对照组中，增殖期和分泌期的壶腹部和伞部产生的PGE和PGF比峡部更多。壶腹部和伞部的PGE生成量在增殖期和分泌期增加。PGF生成量在各部位的增殖期均占主导。6-酮-PGF1α和血栓素B2的生成量无明显的周期性或区域性变化。
结论
在子宫内膜异位症患者中，峡部和壶腹部在增殖期产生的PGE和PGF比正常对照组多得多。子宫内膜异位症中PGF/PGE比值的变化与正常对照组不同。显然，子宫内膜异位症中输卵管的PG生成发生了改变。
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