子宫内膜异位症女性痛经严重程度与前列腺素产生之间的相关性。
Correlation between dysmenorrheic severity and prostaglandin production in women with endometriosis.
作者信息
Koike H, Egawa H, Ohtsuka T, Yamaguchi M, Ikenoue T, Mori N
机构信息
Department of Obstetrics and Gynecology, Miyazaki Medical College, Japan.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 1992 Jun;46(2):133-7. doi: 10.1016/0952-3278(92)90219-9.
The role of prostaglandins (PGs) in dysmenorrhea of endometriosis is poorly understood. The relationship between dysmenorrheic severity and prostaglandin production was investigated in endometriosis. Slices of normal myometrium, adenomyosis, normal ovary and endometrial cyst were incubated. 6-Keto-PGF1 alpha (a metabolite of PGI2), TXB2 (a metabolite of TXA2), PGF2 alpha, and PGE2 concentrations of the incubation medium were measured by RIA. The results showed that 6-keto-PGF1 alpha production in adenomyosis and endometrial cyst were significantly higher than those in normal myometrium and ovary. A direct relationship between the degree of dysmenorrheic severity and PGs production in tissue in endometriosis was observed.
前列腺素（PGs）在子宫内膜异位症痛经中的作用尚不清楚。研究了子宫内膜异位症中痛经严重程度与前列腺素产生之间的关系。对正常子宫肌层、子宫腺肌病、正常卵巢和子宫内膜囊肿的切片进行孵育。通过放射免疫分析法测定孵育培养基中6-酮-前列环素F1α（前列环素I2的一种代谢产物）、血栓素B2（血栓素A2的一种代谢产物）、前列腺素F2α和前列腺素E2的浓度。结果显示，子宫腺肌病和子宫内膜囊肿中6-酮-前列环素F1α的产生显著高于正常子宫肌层和卵巢。观察到子宫内膜异位症组织中痛经严重程度与PGs产生之间存在直接关系。
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