脂磷壁酸和脂质对粪肠球菌细胞壁自溶的抑制作用。
Inhibition of wall autolysis in Streptococcus faecalis by lipoteichoic acid and lipids.
作者信息
Cleveland R F, Wicken A J, Daneo-Moore L, Shockman G D
出版信息
J Bacteriol. 1976 Apr;126(1):192-7. doi: 10.1128/jb.126.1.192-197.1976.
Fully acylated lipoteichoic acid (LTA) isolated from Streptococcus faecalis ATCC9790 (S. faecium) inhibited autolysis of walls from the same organism at concentrations (1.0 to 1.5 nmol of LTA per mg of wall) comparable to those found in intact cells. Partially deacylated LTA isolated from S. faecalis or chemically deacylated LTA failed to inhibit significantly in the same concentration range. Beef heart cardiolipin and commercially obtained dipalmitoyl phosphatidyl glycerol were also found to inhibit wall autolysis in S. faecalis. Chemical deacylation of beef heart cardiolipin also removed the inhibitory activity of this molecule. Lipid fractions isolated from S. faecalis that inhibited wall autolysis were: diphosphatidyl glycerol (cardiolipin), phosphatidyl glycerol, aminoacyl phosphatidyl glycerol, and a neutral lipid fraction. Glycolipids were not found to be effective inhibitors. The possible role of LTA and/or certain lipids as regulators of cellular autolytic activity is discussed.
从粪肠球菌ATCC9790（屎肠球菌）中分离出的完全酰化脂磷壁酸（LTA），在与完整细胞中发现的浓度相当（每毫克细胞壁1.0至1.5纳摩尔LTA）的情况下，抑制了同一生物体细胞壁的自溶作用。从粪肠球菌中分离出的部分脱酰LTA或化学脱酰的LTA在相同浓度范围内未能显著抑制。还发现牛心磷脂和市售的二棕榈酰磷脂酰甘油也能抑制粪肠球菌的细胞壁自溶。牛心磷脂的化学脱酰作用也消除了该分子的抑制活性。从粪肠球菌中分离出的抑制细胞壁自溶的脂质部分有：二磷脂酰甘油（心磷脂）、磷脂酰甘油、氨基酰磷脂酰甘油和一个中性脂质部分。未发现糖脂是有效的抑制剂。讨论了LTA和/或某些脂质作为细胞自溶活性调节剂的可能作用。
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