Tree-structured non-linear filter and wavelet transform for microcalcification segmentation in digital mammography.

A novel algorithm was developed for computer aided diagnosis of microcalcification clusters in digital mammography. The method includes: (a) tree-structured central weighted median filters with variable shape windowing to suppress image noise but preserve image details; (b) a quasi range dispersion edge detector to increase edge contrast and definition; and (c) tree-structured wavelets for calcification segmentation. The preliminary evaluation of the method on nine mammograms showed that 100% sensitivity can be achieved at the expense of four false positive clusters per image. Research is ongoing for further optimization of the algorithm to reduce the number of false alarms and establish its clinical value.