针对一种间日疟原虫样人类疟原虫和食蟹猴疟原虫环子孢子蛋白重复序列的单克隆抗体。
Monoclonal antibodies to the circumsporozoite protein repeats of a Plasmodium vivax-like human malaria parasite and Plasmodium simiovale.
作者信息
Udhayakumar V, Qari S H, Patterson P, Collins W E, Lal A A
机构信息
Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia 30333.
出版信息
Infect Immun. 1994 May;62(5):2098-100. doi: 10.1128/iai.62.5.2098-2100.1994.
Abstract
We have recently described a Plasmodium vivax-like human malaria parasite. The circumsporozoite protein of this parasite is identical to that of a simian malaria parasite, P. simiovale, but different from two known types of P. vivax. Here, we describe the production of two monoclonal antibodies, Pam 172 and Pam 135, specific for the circumsporozoite protein repeat sequence APGANQEGGAA of the P. vivax-like malaria parasite. These two monoclonal antibodies recognized air-dried sporozoites of P. simiovale but not other human, simian, or rodent malaria parasites tested.
摘要
我们最近描述了一种类似间日疟原虫的人类疟原虫。这种疟原虫的环子孢子蛋白与一种猴疟原虫——卵形疟原虫的环子孢子蛋白相同，但与两种已知类型的间日疟原虫不同。在此，我们描述了两种单克隆抗体Pam 172和Pam 135的产生，它们对类似间日疟原虫的疟原虫的环子孢子蛋白重复序列APGANQEGGAA具有特异性。这两种单克隆抗体识别卵形疟原虫的空气干燥子孢子，但不识别所测试的其他人类、猴或啮齿类疟原虫。
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