不同淋病奈瑟菌菌株之间过氧化氢敏感性的差异除了取决于过氧化氢酶活性外，还取决于其他因素。
Variation in hydrogen peroxide sensitivity between different strains of Neisseria gonorrhoeae is dependent on factors in addition to catalase activity.
作者信息
Alcorn T M, Zheng H Y, Gunther M R, Hassett D J, Cohen M S
机构信息
Department of Medicine, University of North Carolina at Chapel Hill 27599-7030.
出版信息
Infect Immun. 1994 May;62(5):2138-40. doi: 10.1128/iai.62.5.2138-2140.1994.
Catalase, which catalyzes the reduction of hydrogen peroxide to oxygen and water, is considered the primary defense of Neisseria gonorrhoeae against exogenous hydrogen peroxide. Recent reports have demonstrated drastically different sensitivities of the organism to hydrogen peroxide ranging from greater than 80% survival after challenge with 30 mM hydrogen peroxide to less than 0.001% survival after challenge with 10 mM hydrogen peroxide. In this study, we have examined the hydrogen peroxide sensitivities of six clinical gonococcal isolates. The study demonstrates that the variations in gonococcal hydrogen peroxide sensitivities previously reported can be attributed to (i) differences in experimental methods employed or (ii) variation among different gonococcal strains. All of the gonococcal isolates examined generated similar concentrations of catalase, implying that the differences in the H2O2 sensitivity observed may depend on factors in addition to catalase.
过氧化氢酶可催化过氧化氢还原为氧气和水，它被认为是淋病奈瑟菌抵御外源性过氧化氢的主要防御机制。最近的报告显示，该生物体对过氧化氢的敏感性差异极大，在用30 mM过氧化氢攻击后存活率大于80%，而在用10 mM过氧化氢攻击后存活率小于0.001%。在本研究中，我们检测了6株临床淋病奈瑟菌分离株对过氧化氢的敏感性。该研究表明，先前报道的淋病奈瑟菌对过氧化氢敏感性的差异可归因于：（i）所采用的实验方法不同，或（ii）不同淋病奈瑟菌菌株之间的差异。所有检测的淋病奈瑟菌分离株产生的过氧化氢酶浓度相似，这意味着观察到的对H2O2敏感性的差异可能取决于除过氧化氢酶之外的其他因素。
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