Goletti O, Monzani F, Lenziardi M, Lippolis P V, De Negri F, Caraccio N, Cavina E, Baschieri L
Department of Emergency Surgery, University of Pisa, Italy.
J Clin Ultrasound. 1994 Mar-Apr;22(3):175-8. doi: 10.1002/jcu.1870220305.
Sonographically guided percutaneous ethanol injection (PEI) has been recently used with excellent results in the treatment of toxic and pretoxic thyroid adenoma. The aim of the present study was to assess the efficacy of PEI also in the treatment of "cold" thyroid nodules. Twenty patients, each with a single thyroid nodule, underwent PEI. In all cases the nodules were found to be cold by thyroid scintiscan. A total of 16.1 mL +/- 3.1 mL of ethanol was injected once a week. No adverse effects were observed during therapy. A striking nodular shrinkage was obtained in all cases, ranging from 72.8% to 97.6% (mean 84.5%, p < 0.001 vs pretreatment volume). These preliminary results suggest that PEI is an effective and safe therapy that may be useful in the treatment of thyroid nodules as an alternative to other therapies (surgery, L-thyroxine).
超声引导下经皮乙醇注射（PEI）最近已用于治疗毒性和毒性前期甲状腺腺瘤，并取得了良好效果。本研究的目的是评估PEI在治疗“冷”甲状腺结节中的疗效。20例患者，每人有一个甲状腺结节，接受了PEI治疗。所有病例的结节经甲状腺闪烁扫描均显示为冷结节。每周注射一次乙醇，总量为16.1 mL±3.1 mL。治疗期间未观察到不良反应。所有病例均出现明显的结节缩小，范围为72.8%至97.6%（平均84.5%，与治疗前体积相比，p<0.001）。这些初步结果表明，PEI是一种有效且安全的治疗方法，作为其他治疗方法（手术、左旋甲状腺素）的替代方法，可能对治疗甲状腺结节有用。
