Chen L, Gu Y D
Hand Surgery Institute, Hua-Shan Hospital, Shanghai Medical University, People's Republic of China.
J Hand Surg Br. 1994 Feb;19(1):60-6. doi: 10.1016/0266-7681(94)90051-5.
Experimental rat models of simulated brachial plexus injuries were devised to compare the effect of contralateral C7 root transfer with phrenic neurotization. The effect of vascularized nerve grafting (VNG) was also compared with the use of conventional nerve grafts (CNG) in the treatment of root avulsion of the brachial plexus. 160 rats were randomly divided into four groups of 40 each; contralateral C7 root transfer with a vascularized ulnar nerve graft (C7-VNG), contralateral C7 root transfer with conventional ulnar nerve grafting (C7-CNG), ipsilateral phrenic nerve transfer with a vascularized ulnar nerve graft (P-VNG) and ipsilateral phrenic nerve transfer with conventional ulnar nerve grafting (P-CNG). Electrophysiological and histological examinations and functional evaluation were performed at different post-operative intervals. C7 root transfer was found to be superior to phrenic nerve transfer and VNG superior to CNG. Severance of the C7 nerve root was not found to affect limb function on the healthy side.
设计了模拟臂丛神经损伤的实验大鼠模型，以比较对侧C7神经根转移与膈神经移位的效果。还比较了血管化神经移植（VNG）与传统神经移植（CNG）在治疗臂丛神经根撕脱中的效果。160只大鼠被随机分为四组，每组40只；对侧C7神经根转移联合血管化尺神经移植（C7-VNG）、对侧C7神经根转移联合传统尺神经移植（C7-CNG）、同侧膈神经移位联合血管化尺神经移植（P-VNG）和同侧膈神经移位联合传统尺神经移植（P-CNG）。在不同的术后时间间隔进行电生理和组织学检查以及功能评估。发现C7神经根转移优于膈神经移位，VNG优于CNG。未发现切断C7神经根会影响健康侧的肢体功能。
